Phentermine hcl 30 mg capsules

By | 20.01.2018

phentermine hcl 30 mg capsules

Use caution when administering Phentermine to patients with renal impairment [ see Clinical Pharmacology Capsules produced by Lannett, contain Phentermine in form of resins, equal to 30 mg and 15 mg of base substance. Abuse of amphetamines and related drugs may be associated with intense psychological dependence and severe social dysfunction. Phentermine is used with a doctor-approved exercise , behavior change, and reduced-calorie diet program to help you lose weight. Do not crush or chew sustained-release capsules.

Phentermine is related chemically and pharmacologically to amphetamine d- and dll-amphetamine and other related stimulant drugs have been extensively abused. The possibility of abuse of phentermine should be kept in mind when evaluating the desirability of including a drug as part of a weight reduction program. See Drug Abuse and Dependence 9 and Overdosage Concomitant use of alcohol with Phentermine may result in an adverse drug reaction.

Use caution in prescribing Phentermine for patients with even mild hypertension risk of increase in blood pressure. A reduction in insulin or oral hypoglycemic medications in patients with diabetes mellitus may be required. The following adverse reactions are described, or described in greater detail, in other sections:. Overstimulation, restlessness, dizziness, insomnia, euphoria, dysphoria, tremor, headache; rarely psychotic episodes at recommended doses.

Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances. Use of Phentermine is contraindicated during or within 14 days following the administration of monoamine oxidase inhibitors because of the risk of hypertensive crisis. Concomitant use of alcohol with phentermine may result in an adverse drug reaction.

Requirements may be altered [ see Warnings and Precautions 5. Phentermine may decrease the hypotensive effect of adrenergic neuron blocking drugs. Phentermine is contraindicated during pregnancy because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm. A minimum weight gain, and no weight loss, is currently recommended for all pregnant women, including those who are already overweight or obese, due to obligatory weight gain that occurs in maternal tissues during pregnancy.

Phentermine has pharmacologic activity similar to amphetamine d- and dll-amphetamine [ see Clinical Pharmacology Animal reproduction studies have not been conducted with phentermine. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus.

It is not known if Phentermine is excreted in human milk; however, other amphetamines are present in human milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Safety and effectiveness in pediatric patients have not been established. Because pediatric obesity is a chronic condition requiring long-term treatment, the use of this product, approved for short-term therapy, is not recommended. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Phentermine was not studied in patients with renal impairment. Based on the reported excretion of Phentermine in urine, exposure increases can be expected in patients with renal impairment.

Use caution when administering Phentermine to patients with renal impairment [ see Clinical Pharmacology Phentermine is related chemically and pharmacologically to the amphetamines. Amphetamines and other stimulant drugs have been extensively abused and the possibility of abuse of phentermine should be kept in mind when evaluating the desirability of including a drug as part of a weight reduction program. Abuse of amphetamines and related drugs may be associated with intense psychological dependence and severe social dysfunction.

There are reports of patients who have increased the dosage of these drugs to many times than recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. Manifestations of chronic intoxication with anorectic drugs include severe dermatoses, marked insomnia, irritability, hyperactivity and personality changes.

A severe manifestation of chronic intoxication is psychosis, often clinically indistinguishable from schizophrenia. Manifestations of acute overdosage include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, and panic states. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include arrhythmia, hypertension or hypotension, and circulatory collapse.

Gastrointestinal symptoms include nausea, vomiting, diarrhea and abdominal cramps. Overdosage of pharmacologically similar compounds has resulted in fatal poisoning usually terminates in convulsions and coma. Management of acute phentermine hydrochloride intoxication is largely symptomatic and includes lavage and sedation with a barbiturate.

Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendations in this regard. Acidification of the urine increases phentermine excretion. The most severe manifestation of chronic intoxications is psychosis, often clinically indistinguishable from schizophrenia. See Drug Abuse and Dependence 9. The structural formula is as follows:. Phentermine Hydrochloride is a white, odorless, hygroscopic, crystalline powder which is soluble in water and lower alcohols; slightly soluble in chloroform and insoluble in ether.

Phentermine is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, amphetamine d- and d l l-amphetamine. Typical of amphetamines include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.

Following the administration of Phentermine, Phentermine reaches peak concentrations Cmax after 3 to 4. Exposure increases can be expected in patients with renal impairment. Use caution when administering phentermine to patients with renal impairment. This is how tablets were born. Tablets or pills are the most common pharmaceutical form of drugs in the world. Phentermine tablets contain medical ingredients in a pressed form for oral intake.

Phentermine pills have been used for treatment of obesity since Since that time, Phentermine pills have become a well-known medication for weight loss. After a person takes Phentermine pill orally, some time passes before the active substance is absorbed into blood. First of all, it takes time for the tablet starts swelling, disintegrating and releasing the active substance. It is one of the disadvantages of Phentermine tablets.

Unlike capsules, Phentermine pills can be divided into two pieces and thus patient can control the dosage. You can find Phentermine tablets at the USA pharmacies in the dose of 15 mg, 30 mg or Encapsulation is one of the modern pharmaceutical forms of medications. Capsule is believed to be a small cylindrical shell, which is easily dissolved in the gastrointestinal tract GIT. Inside the capsule, you may find one or more active ingredients that are absorbed into the blood much faster than tablets.

As said above, Phentermine capsules have cylindrical shape, designed for easy oral application. Many overweight or obese patients believe that it is much easier to swallow Phentermine capsules, than tablets. Phentermine capsules must not be divided and thus, they are produced in different dosages 15 mg, 30 mg or At the USA pharmacies, you only can buy capsules of

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