Phentermine may decrease the hypotensive effect of adrenergic neuron blocking drugs. Overdosage of pharmacologically similar compounds has resulted in fatal poisoning usually terminates in convulsions and coma. Therefore, coadministration of phentermine and these drug products is not recommended. The possible origins of the increased weight loss due to the various drug effects are not established. The clinical significance of these differences is not known. There are reports of patients who have increased the dosage of these drugs to many times than recommended. How To Lose Weight: Phentermine
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