Phentermine dosage forms slideshare presentation

By | 20.04.2018

phentermine dosage forms slideshare presentation

The best is to purchase 3 bottles of Phentermine online without prescription. They all took Embeds 0 No embeds. Packaging and storing modified-release tablets and capsules 3. Now customize the name of a clipboard to store your clips.

Are you sure you want to Yes No. Embeds 0 No embeds. No notes for slide. Modified release drug products 1. Orally disintegrating tablet 3. Examples of modified release dosage forms Systems Examples of drugs Oral drug products Diltiazem HCL extended release Diclofenac sodium delayed release Ondansetron oral soluble film Transdermal drug delivery system Clonidine transdermal therapeutic system Opthalmic drug delivery Controlled release pilocarpine Intravaginal drug delivery Dinoprostone vaginal insert 7.

By this process, the drug substance is combined and made into granules with an excipient material that slowly erodes in body fluids, progressively releasing the drug for absorption. When these granules are mixed with granules of drug prepared without the excipient, the uncombined granules provide the immediate drug effect whereas the drug-excipient granules provide extended drug action. The mechanism of action of drug release In the stomach: In the intestine 1.

Osmotic core containing drug Osmotic delivery orifice Semipermeable membrane Osmotic pressure-controlled drug delivery system The drug-release rate is not affected by gastrointestinal acidity, alkalinity, fed conditions, or GI motility. Effect of coating membrane thickness on the rate and duration of zero-order release of indomethacin from osmotic pressure-controlled gastrointestinal delivery system Maintained above the minimum effective drug concentration.

You just clipped your first slide! Packaging and storing modified-release tablets and capsules 3. The delay may be time-based or based on the influence of environmental conditions, as gastrointestinal pH. Extended-release oral dosage forms 1. Drug-candidates for extended- release products The drugs best suited for incorporation into an extended- release product have the following characteristics: The rate of drug release from solid dosage forms may be modified by the technologies described below: Extended-release technology for oral dosage forms By this process, the drug substance is combined and made into granules with an excipient material that slowly erodes in body fluids, progressively releasing the drug for absorption.

When these granules are mixed with granules of drug prepared without the excipient, the uncombined granules provide the immediate drug effect whereas the drug-excipient granules provide extended drug action. The mechanism of action of drug release In the stomach: In the intestine 1. Osmotic core containing drug Osmotic delivery orifice Semipermeable membrane Osmotic pressure-controlled drug delivery system The drug-release rate is not affected by gastrointestinal acidity, alkalinity, fed conditions, or GI motility.

Effect of coating membrane thickness on the rate and duration of zero-order release of indomethacin from osmotic pressure-controlled gastrointestinal delivery system Delayed-release oral dosage forms The release of a drug from an oral dosage form may be intentionally delayed until it reaches the intestines for several reasons. USP requirements and FDA guidance for modified-release dosage forms 1 Drug release The USP test for drug release for extended- release and delayed-release articles is based on drug dissolution from the dosage unit against elapsed test time.

Time hr Amount dissolved 1. Assessing IVIVCs is important throughout the periods of product development, clinical evaluation, submission of an application for FDA- approval for marketing, and during postapproval for any formulation or Packaging and storing modified- release tablets and capsules Modified-release tablets and capsules are packaged and stored in the same manner as conventional products.

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