An overdose of phentermine can be fatal. Use of Phentermine is contraindicated during or within 14 days following the administration of monoamine oxidase inhibitors because of the risk of hypertensive crisis. Keep the medication in a place where others cannot get to it. Healthy Habits for Weight Loss Slideshow. Ask your doctor before taking phentermine with diet pills, other stimulants, or medicine to treat attention deficit hyperactivity disorder ADHD. The possibility of abuse of Phentermine should be kept in mind when evaluating the desirability of including a drug as part of a weight reduction program. Surprising Sources of Hidden Sugar. If You’re On Any Of These Medications, DO NOT Use Apple Cider Vinegar
There is no evidence that phentermine is safe for women who are pregnant. Other adverse effects include: Phentermine has some similarity in its pharmacodynamics with its parent compound, amphetamine , as they both are TAAR1 agonists ,  where the activation of TAAR1 in monoamine neurons facilitates the efflux or, release into the synapse, of these neurochemicals; at clinically relevant doses, phentermine primarily acts as a releasing agent of norepinephrine in neurons , although, to a lesser extent, it releases dopamine and serotonin into synapses as well.
The primary mechanism of phentermine's action in treating obesity is the reduction of hunger perception, which is a cognitive process mediated primarily through several nuclei within the hypothalamus in particular, the lateral hypothalamic nucleus , arcuate nucleus , and ventromedial nucleus. Outside the brain, phentermine releases norepinephrine and epinephrine — also known as noradrenaline and adrenaline respectively — causing fat cells to break down stored fat as well.
In , phentermine first received approval from the United States FDA as an appetite-suppressing drug. Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. In , after 24 cases of heart valve disease in fen-phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. Phentermine is still available by itself in most countries, including the US.
In contrast, amphetamine preparations are classified as Schedule II controlled substances. Phentermine can be produced from benzaldehyde and 2-nitropropane as follows: From Wikipedia, the free encyclopedia. S4 Prescription only CA: NC Cc1ccccc1 C C. Retrieved 16 November Retrieved 13 October Archives of Internal Medicine.
International Journal of Clinical Practice. Sympathomimetic Drugs in the Management of Obesity". In Bray, George A. Retrieved 12 July The Journal of Clinical Endocrinology and Metabolism. Fastin phentermine hydrochloride is a type of appetite suppressant called a sympathomimetic amine used in the management of exogenous obesity over the short term a few weeks as an adjunct to a regimen of weight reduction based on caloric restriction.
The brand name drug Fastin is no longer available in the U. A generic version is available. Side effects of Fastin include:. The recommended dose of Fastin is one capsule 30 mg a day taken approximately 2 hours after breakfast for appetite control. Late evening medication should be avoided because of the possibility of resulting insomnia. Fastin may interact with alcohol.
Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Fastin; it is unknown if it would affect a fetus. Consult your doctor before breastfeeding. Withdrawal symptoms may occur if you suddenly stop taking Fastin. Our Fastin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur.