Get phentermine Price Alerts. It is available in generic and brand versions. It was first introduced in , and became part of the drug combination fen-phen that was withdrawn from the market in due to the fenfluramine component damaging people's heart valves. Different formulations of phentermine as a single agent are available under various brand names, in many countries. Price drops for your prescriptions New coupons and savings alerts Drug recalls and FDA alerts Please enter your email address A valid email is required. GoodRx provides no warranty for any of the pricing data or other information.
Phentermine use is contraindicated in those who: Phentermine may decrease the effect of drugs like clonidine , methyldopa , and guanethidine. Drugs to treat hypothyroidism may increase the effect of phentermine. Rare cases of pulmonary hypertension and cardiac valvular disease have been reported. There is no evidence that phentermine is safe for women who are pregnant.
Other adverse effects include: Phentermine has some similarity in its pharmacodynamics with its parent compound, amphetamine , as they both are TAAR1 agonists ,  where the activation of TAAR1 in monoamine neurons facilitates the efflux or, release into the synapse, of these neurochemicals; at clinically relevant doses, phentermine primarily acts as a releasing agent of norepinephrine in neurons , although, to a lesser extent, it releases dopamine and serotonin into synapses as well.
The primary mechanism of phentermine's action in treating obesity is the reduction of hunger perception, which is a cognitive process mediated primarily through several nuclei within the hypothalamus in particular, the lateral hypothalamic nucleus , arcuate nucleus , and ventromedial nucleus. Outside the brain, phentermine releases norepinephrine and epinephrine also known as noradrenaline and adrenaline respectively causing fat cells to break down stored fat as well.
In , phentermine first received approval from the United States FDA as an appetite-suppressing drug. Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. In , after 24 cases of heart valve disease in fen-phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA.
Phentermine is still available by itself in most countries, including the US. In contrast, amphetamine preparations are classified as Schedule II controlled substances. Phentermine can be produced from benzaldehyde and 2-nitropropane as follows: From Wikipedia, the free encyclopedia. S4 Prescription only CA: NC Cc1ccccc1 C C. Retrieved 16 November Retrieved 13 October Archives of Internal Medicine. International Journal of Clinical Practice.
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