Share Email Print Feedback Close. As a drug related to the amphetamines, phentermine has the potential to cause serotonin syndrome when combined with serotonergic agents. Can cause changes in laboratory values; can increase the risk of hypokalemia through its inhibition of carbonic anhydrase activity; caution with coadministration of drug that cause hypokalemia eg, furosemide, hydrochlorothiazide. Now it's your turn: Traditional advice is to take the medication daily for several months, then stop it.
Significant - Monitor Closely. All Interactions Sort By: Postmarketing Reports Phentermine Allergic: Increased blood pressure, ischemic events CNS: Euphoria, psychosis, tremor Reproductive: Changes in libido, impotence. Topiramate Central nervous system: Suicidal behavior and ideation Dermatologic: Bullous skin reactions eg, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis , pemphigus Gastrointestinal: Hepatic failure including fatalities , hepatitis Metabolic: Maculopathy, angle closure glaucoma, increased intraocular pressure.
Warnings Contraindications Hypersensitivity or idiosyncrasy to sympathomimetic amines Pregnancy Glaucoma Hyperthyroidism Use of phentermine is contraindicated during or within 14 days following MAOIs due to risk for hypertensive crisis. X Can cause fetal harm and weight loss offers no potential benefit to a pregnant woman Available epidemiologic data indicate an increased risk in oral clefts of 9.
Distributed in breast milk; because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug Pregnancy Categories A: Pharmacology Mechanism of Action Phentermine: Sympathomimetic amine; induces anorectic effect via release of norepinephrine in the hypothalamus causing appetite suppression by increasing blood leptin concentration; exact mechanism of action unknown Topiramate: Absorption Phentermine 15 mg dose Peak Plasma Time: Topiramate 92 mg dose Peak Plasma Time: Distribution Phentermine Protein Bound: Metabolism Phentermine Metabolized by 2 metabolic pathways, p-hydroxylation on the aromatic ring and N-oxidation on the aliphatic side chain CYP3A4 primarily metabolizes phentermine but does not show extensive metabolism Monoamine oxidase MAO -A and MAO-B do not metabolize phentermine.
Topiramate Not extensively metabolized. Print without Office Info. Print with Office Info. Formulary Formulary Patient Discounts. Create Your List of Plans. View explanations for tiers and restrictions. Tier Description 1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs. Most commonly, these are "preferred" on formulary brand drugs. Most commonly, these are "non-preferred" brand drugs. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
This restriction requires that specific clinical criteria be met prior to the approval of the prescription. QL Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered. ST Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription. OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Applies to the following strengths: Print this page Add to My Med List. Guide to Weight Loss Drugs.